This week with a client I saw ext4 used for the first time on a production MySQL system which was running Ubuntu 9.10 (Karmic Koala). I observe today while installing 9.10 Server locally that ext4 is the default option. The ext4 filesystem is described as better performance, reliability and features while there is also information about improvements in journaling.
At OSCON 2009 I attended a presentation on Linux Filesystem Performance for Databases by Selena Deckelmann in which ext4 was included. While providing some improvements in sequential reading and writing, there were issue with random I/O which is the key for RDBMS products.
Is the RAID configuration (e.g. RAID 5, RAID 10), strip size, buffer caches, LVM …
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